Methylamine → 4-((Methylamino)methyl)thiazol-2-amine

HRID 1366661Notes

Reaction equation

HRID 1366661 reaction equation
Cl[CH2:2][C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1.[CH3:9][NH2:10]>>[CH3:9][NH:10][CH2:2][C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 732294-Chloromethylthiazol-2-ylamine

Product 1

HCID 189398714-((Methylamino)methyl)thiazol-2-amineYield 15%

Procedure

4-(Chloromethyl)-1,3-thiazol-2-amine (490 mg, 2.65 mmol) was stirred in 40% aqueous methylamine (25 ml) overnight. The reaction mixture was evaporated. The residue was then purified via reverse phase HPLC to provide 4-[(methylamino)methyl]-1,3-thiazol-2-amine (55 mg, 15%). LCMS: (M+H)+: 144.0.

Workup

  1. customThe reaction mixture was evaporated
  2. customThe residue was then purified via reverse phase HPLC

Sources & evidence

ORD record
ord-8a009e6420384e36a659e61a3afe57cc
Source dataset
uspto-grants-2011_02
Patent number
US07893056B2

Reaction notes

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