Hydrochloric Acid → (S)-N,N-Dimethyl(pyrrolidin-2-yl)methanamine hydrochloride

N,N-Dimethyl-1-[(2S)-1-(phenylmethyl)-2-pyrrolidinyl]methanamine (3.730 g, 17.08 mmol) was dissolved in a mixture of MeOH (100 mL) and 1N HCl (35 mL, 34.16 mmol), degassed and placed under argon. 10% Pd/C (1.119 g) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon for 2 h. The contents were then degassed, and the Pd/C was removed by filtration through a fiberglass filter, washing with MeOH. The filtrate was concentrated in vacuo to provide pure N,N-dimethyl-1-[(2S)-2-pyrrolidinyl]methanamine hydrochloride (3.3701 g, >99%). LCMS: (M+H)+: 129.1.

1. customdegassed
2. addition10% Pd/C (1.119 g) was added
3. customthe contents were thoroughly degassed
4. customfor 2 h
5. customThe contents were then degassed
6. customthe Pd/C was removed by filtration through a fiberglass
7. filtrationfilter
8. washwashing with MeOH
9. concentrationThe filtrate was concentrated in vacuo

ORD record

ord-440e6e5a58ad45cdabb196372a586223

Source dataset

uspto-grants-2011_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07893056B2