Hydrochloric Acid → (2S)-N,N-dimethyl-2-piperidinecarboxamide hydrochloride

Participants

Reaction Steps

Phenylmethyl (2S)-2-[(dimethylamino)carbonyl]-1-piperidinecarboxylate (1.918 g, 6.609 mmol) was dissolved in a mixture of MeOH (40 mL) and 1N HCl (14.53 mL, 14.53 mmol), degassed and placed under argon. 10% Pd/C (575 mg) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon for 2 h. The contents were then degassed, and the Pd/C was removed by filtration through a fiberglass filter, washing with MeOH. The filtrate was concentrated in vacuo to provide pure (2S)—N,N-dimethyl-2-piperidinecarboxamide hydrochloride (1.483 g, >99%). LCMS: (M+H)+: 157.2.

Provenance & Evidence