反应详情

Phenylmethyl (2S)-2-[(dimethylamino)carbonyl]-1-piperidinecarboxylate (1.918 g, 6.609 mmol) was dissolved in a mixture of MeOH (40 mL) and 1N HCl (14.53 mL, 14.53 mmol), degassed and placed under argon. 10% Pd/C (575 mg) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon for 2 h. The contents were then degassed, and the Pd/C was removed by filtration through a fiberglass filter, washing with MeOH. The filtrate was concentrated in vacuo to provide pure (2S)—N,N-dimethyl-2-piperidinecarboxamide hydrochloride (1.483 g, >99%). LCMS: (M+H)+: 157.2.

1. customdegassed
2. addition10% Pd/C (575 mg) was added
3. customthe contents were thoroughly degassed
4. customfor 2 h
5. customThe contents were then degassed
6. customthe Pd/C was removed by filtration through a fiberglass
7. filtrationfilter
8. washwashing with MeOH
9. concentrationThe filtrate was concentrated in vacuo