反应详情

温度

125 °C

A mixture of 6-methoxy-7-methylisoquinolin-1-ylamine (5.11 g, 27.18 mmol) and 48% aqueous hydrobromic acid (150 ml) was heated at 125° C. for 2 days. The mixture was concentrated in vacuo and triturated with diethyl ether, dried in vacuo to give 1-amino-7-methyl-isoquinolin-6-ol hydrobromide (5 g), EIMS: m/z=175.1 [M+H]+. 1H NMR (DMSO-D6) δ7.06 (1H, d), 7.16 (1H, d) , 7.25 (1H, dd), 7.56 (1H, d), 8.44 (1H, dd), 8.66 (2H, broad s), 11.05 (1H, s), 12.45 (1H, s).

1. concentrationThe mixture was concentrated in vacuo
2. customtriturated with diethyl ether
3. customdried in vacuo