HCID 178486052, compound → HCID 178484836, compound

HRID 1366761Notes

Reaction equation

HRID 1366761 reaction equation
C(O[C:6](=O)[N:7](C)[C@H:8]1[CH2:13][CH2:12][C@H:11]([O:14][C:15]2[CH:16]=[C:17]3[C:22](=[CH:23][CH:24]=2)[C:21](=[O:25])[NH:20][CH:19]=[CH:18]3)[CH2:10][CH2:9]1)(C)(C)C>ClCCl.FC(F)(F)C(O)=O>[CH3:6][NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([O:14][C:15]2[CH:16]=[C:17]3[C:22](=[CH:23][CH:24]=2)[C:21](=[O:25])[NH:20][CH:19]=[CH:18]3)[CH2:10][CH2:9]1

Participants

4

Reactant 1

HCID 178486052HCID 178486052, compound

Product 1

HCID 178484836HCID 178484836, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of trans-methyl[4-(1-oxo-1,2-dihydroisoquinolin-6-yloxy)cyclohexyl]-carbamic acid tert-butyl ester (400 mg, 1.07 mmol) in dichloromethane (9 ml) and trifluoroacetic acid (1 ml) was stirred at ambient temperature for 1 hour. The mixture was concentrated in vacuo then purified by ion exchange chromatography to give trans-6-(4-methylaminocyclohexyloxy)-2H-isoquinolin-1-one, EI-MS: m/z=273.4 [M+H]+.

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customthen purified by ion exchange chromatography

Sources & evidence

ORD record
ord-82db64825b744c8fbd7d0384a7914f03
Source dataset
uspto-grants-2011_02
Patent number
US07893088B2

Reaction notes

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