Hydrochloric Acid → HCID 17973690, compound

Participants

Reaction Conditions

Reaction Steps

5-(4-Fluoro-phenyl)-2-methyl-2H-[1,2,3]triazole-4-carboxylic acid methyl ester D24 (940 mg, 4 mmol) in water (65 ml) was treated with 2N sodium hydroxide (4 ml) and the mixture was heated at 120° C. for 2 h. The volume of water was reduced to 20 ml in vacuo and the ice-cooled residue was treated with 2N HCl (4 ml). Filtration, washing with water and drying in vacuo afforded the title compound as a white solid (810 mg, 91%). Mass spectrum (API+). Found 222 (MH+) C10H8FN3O2 requires 221.

Provenance & Evidence