Hydrochloric Acid → HCID 17973690, compound

HRID 1366988Notes

Reaction equation

HRID 1366988 reaction equation
C[O:2][C:3]([C:5]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[N:8][N:7]([CH3:17])[N:6]=1)=[O:4].[OH-].[Na+].Cl>O>[F:16][C:13]1[CH:14]=[CH:15][C:10]([C:9]2[C:5]([C:3]([OH:4])=[O:2])=[N:6][N:7]([CH3:17])[N:8]=2)=[CH:11][CH:12]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66968351HCID 66968351, compound

Product 1

HCID 17973690HCID 17973690, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
120 °C

Procedure

5-(4-Fluoro-phenyl)-2-methyl-2H-[1,2,3]triazole-4-carboxylic acid methyl ester D24 (940 mg, 4 mmol) in water (65 ml) was treated with 2N sodium hydroxide (4 ml) and the mixture was heated at 120° C. for 2 h. The volume of water was reduced to 20 ml in vacuo and the ice-cooled residue was treated with 2N HCl (4 ml). Filtration, washing with water and drying in vacuo afforded the title compound as a white solid (810 mg, 91%). Mass spectrum (API+). Found 222 (MH+) C10H8FN3O2 requires 221.

Workup

  1. filtrationFiltration
  2. washwashing with water
  3. customdrying in vacuo

Sources & evidence

ORD record
ord-1f02214dd03a4254af317c1c0e7d629b
Source dataset
uspto-grants-2011_02
Patent number
US07893090B2

Reaction notes

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