Trifluoroacetic acid → HCID 66973538, compound

HRID 1367151Notes

Reaction equation

HRID 1367151 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@H:9]2[N:14](C(OC(C)(C)C)=O)[C:13](=[O:22])[C:12]([CH3:24])([CH3:23])[O:11][CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:8][C:6]1[CH:5]=[C:4]([C@H:9]2[NH:14][C:13](=[O:22])[C:12]([CH3:24])([CH3:23])[O:11][CH2:10]2)[CH:3]=[C:2]([F:1])[CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66973436HCID 66973436, compound

Product 1

HCID 66973538HCID 66973538, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl (5R)-5-(3,5-difluorophenyl)-2,2-dimethyl-3-oxomorpholine-4-carboxylate from Step F (225 mg, 0.66 mmol) in CH2Cl2 (3 mL) at ambient temperature was added TFA (0.49 mL, 6.6 mmol). After stirring for 1 h, the reaction mixture was concentrated in vacuo to give the title compound. MS: m/z=242 (M+1).

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-de99c1c099514beba6291b18fea6477f
Source dataset
uspto-grants-2011_02
Patent number
US07893079B2

Reaction notes

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