反应详情

1H-Pyrazole-3,5-dicarboxylic acid dimethyl ester (639, 9.1 g, 49.0 mmol) was combined with acetone (400 mL) and potassium carbonate (10.2 g, 74.1 mmol). The mixture was stirred for 40 minutes under an atmosphere of nitrogen. To the stirring suspension, methyl iodide (3.4 mL, 54.0 mmol) was added dropwise. The reaction was stirred at room temperature overnight and then the solvent was evaporated under reduced pressure. The resulting solid was washed with water and filtered. After toluene was added, the solvent was removed under reduced pressure. The resulting compound 640 was used without further purification.

1. stirringThe reaction was stirred at room temperature overnight
2. customthe solvent was evaporated under reduced pressure
3. washThe resulting solid was washed with water
4. filtrationfiltered
5. additionAfter toluene was added
6. customthe solvent was removed under reduced pressure
7. customThe resulting compound 640 was used without further purification