2-Oxa-6-azaspiro[3.3]heptane → HCID 49835732, compound

HRID 1367464Notes

Reaction equation

HRID 1367464 reaction equation
[C:1]1([S:7]([C@H:10]2[CH2:14][C@@H:13]([C:15]([OH:17])=O)[C@H:12]([C:18](=[O:25])[NH:19][C:20]3([C:23]#[N:24])[CH2:22][CH2:21]3)[CH2:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:26]1[C:29]2([CH2:32][NH:31][CH2:30]2)[CH2:28][O:27]1>>[C:23]([C:20]1([NH:19][C:18]([C@@H:12]2[CH2:11][C@@H:10]([S:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)(=[O:8])=[O:9])[CH2:14][C@H:13]2[C:15]([N:31]2[CH2:32][C:29]3([CH2:26][O:27][CH2:28]3)[CH2:30]2)=[O:17])=[O:25])[CH2:21][CH2:22]1)#[N:24]

Participants

3

Reactant 2

HCID 231118872-Oxa-6-azaspiro[3.3]heptaneHCID 49835731HCID 49835731, compound

Product 1

HCID 49835732HCID 49835732, compound

Procedure

The title compound was prepared by reaction of (1R,2R,4R)-4-benzenesulfonyl-2-(1-cyano-cyclopropylcarbamoyl)-cyclopentanecarboxylic acid (example 10) with 2-oxa-6-aza-spiro[3.3]heptane (prepared according to G. Wuitschik et al., Angew. Chem., Int. Ed., 47, 4512, 2008) using a procedure as described in example 1, step 8. Colorless foam. MS: 444.3 (M+H)+.

Sources & evidence

ORD record
ord-87d30603de494b9b85e1c23bba6439c3
Source dataset
uspto-grants-2011_02
Patent number
US07893099B2

Reaction notes

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