Trifluoroacetic acid → HCID 66918566, compound

HRID 1367497Notes

Reaction equation

HRID 1367497 reaction equation
C([O:5][C:6]([CH:8]1[CH2:12][CH2:11][CH:10]([S:13]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=2[Cl:23])(=[O:15])=[O:14])[CH2:9]1)=[O:7])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[Cl:23][C:17]1[CH:18]=[C:19]([F:22])[CH:20]=[CH:21][C:16]=1[S:13]([CH:10]1[CH2:11][CH2:12][CH:8]([C:6]([OH:7])=[O:5])[CH2:9]1)(=[O:15])=[O:14]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 77216805HCID 77216805, compound

Product 1

HCID 66918566HCID 66918566, compoundYield 120%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of Rac-(1S,3S)-3-(2-Chloro-4-fluoro-benzenesulfonyl)-cyclopentanecarboxylic acid tert-butyl ester (278 mg) in dichloromethane (4 mL) was added trifluoroacetic acid (1.34 g). The reaction mixture was stirred overnight at room temperature and the volatiles were removed in vacuo to afford the title compound (282 mg, quant.) as light brown oil, used in the next step without further purification. MS (EI): 305.1 (M−H)−.

Workup

  1. customthe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-770f752ae5614d2c9e0792f24dbdb761
Source dataset
uspto-grants-2011_02
Patent number
US07893099B2

Reaction notes

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