Pyrazole → HCID 59619490, compound

HRID 1367525Notes

Reaction equation

[C:1]([C:3]1([NH:6][C:7]([C@@H:9]2[CH2:13][C@@H:12]([S:14]([C:17]3[CH:22]=[CH:21][C:20](F)=[CH:19][C:18]=3[C:24]([F:27])([F:26])[F:25])(=[O:16])=[O:15])[CH2:11][C@H:10]2[C:28]([N:30]2[CH2:33][C:32]([F:35])([F:34])[CH2:31]2)=[O:29])=[O:8])[CH2:5][CH2:4]1)#[N:2].[NH:36]1[CH:40]=[CH:39][CH:38]=[N:37]1>>[C:1]([C:3]1([NH:6][C:7]([CH:9]2[CH2:13][CH:12]([S:14]([C:17]3[CH:22]=[CH:21][C:20]([N:36]4[CH:40]=[CH:39][CH:38]=[N:37]4)=[CH:19][C:18]=3[C:24]([F:26])([F:27])[F:25])(=[O:16])=[O:15])[CH2:11][CH:10]2[C:28]([N:30]2[CH2:33][C:32]([F:34])([F:35])[CH2:31]2)=[O:29])=[O:8])[CH2:4][CH2:5]1)#[N:2]

Participants

Reactant 2

HCID 1048Pyrazole

HCID 59619447HCID 59619447, compound

Product 1

HCID 59619490HCID 59619490, compound

Procedure

The title compound was prepared in analogy to Example 127 using (1R,2R,4R)-2-(3,3-Difluoro-azetidine-1-carbonyl)-4-(4-fluoro-2-trifluoromethyl-benzenesulfonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide (Example 118) and pyrazole. White foam. MS (EI): 572.14 (M+H)+.

Sources & evidence

ORD record: ord-d53019c74ad4417a9c0e149731a64be3
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07893099B2

Reaction notes

Loading…