1-Ethylpiperazine → HCID 59619498, compound

HRID 1367541Notes

Reaction equation

[C:1]([C:3]1([NH:6][C:7]([C@@H:9]2[CH2:13][C@@H:12]([S:14]([C:17]3[CH:22]=[CH:21][C:20](F)=[CH:19][C:18]=3[Cl:24])(=[O:16])=[O:15])[CH2:11][C@H:10]2[CH2:25][O:26][C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)=[O:8])CC1)#[N:2].[CH2:34]([N:36]1[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1)[CH3:35]>>[C:1]([CH2:3][NH:6][C:7]([C@@H:9]1[CH2:13][C@@H:12]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([N:39]3[CH2:40][CH2:41][N:36]([CH2:34][CH3:35])[CH2:37][CH2:38]3)=[CH:19][C:18]=2[Cl:24])(=[O:16])=[O:15])[CH2:11][C@H:10]1[CH2:25][O:26][C:27]1[CH:28]=[CH:29][C:30]([F:33])=[CH:31][CH:32]=1)=[O:8])#[N:2]

Participants

Reactant 2

HCID 791961-Ethylpiperazine

HCID 59619350HCID 59619350, compound

Product 1

HCID 59619498HCID 59619498, compound

Procedure

The title compound was prepared in analogy to example 127 using (1R,2R,4S)-4-(2-chloro-4-fluoro-benzenesulfonyl)-2-(4-fluoro-phenoxymethyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide (example 145) and 1-ethyl-piperazine. Yellow oil. MS (EI): 563.2 (M+H)+.

Sources & evidence

ORD record: ord-1bbc8d7996e5422aaa4a9e3b660a19b5
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07893099B2

Reaction notes

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