4-Bromo-2-(trifluoromethyl)benzenethiol → HCID 66918793, compound

HRID 1367547Notes

Reaction equation

HRID 1367547 reaction equation
[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][CH:9](OS(C)(=O)=O)[CH2:8][C@H:7]1[CH2:16][O:17][C:18]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:5])[CH3:2].[Br:37][C:38]1[CH:43]=[CH:42][C:41]([SH:44])=[C:40]([C:45]([F:48])([F:47])[F:46])[CH:39]=1>>[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][C@@H:9]([S:44][C:41]2[CH:42]=[CH:43][C:38]([Br:37])=[CH:39][C:40]=2[C:45]([F:48])([F:46])[F:47])[CH2:8][C@H:7]1[CH2:16][O:17][C:18]([C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 509979974-Bromo-2-(trifluoromethyl)benzenethiol2×HCID 86649032HCID 86649032, compound

Product 1

HCID 66918793HCID 66918793, compound

Procedure

The title compound was prepared in analogy to example 68 step 8 using (1R,2R)-4-methanesulfonyloxy-2-trityloxymethyl-cyclopentanecarboxylic acid ethyl ester (epimeric mixture, example 152 step 3) and 4-bromo-2-trifluoromethyl-benzenethiol (example 58, intermediate 1). Colorless oil (43%). MS (EI): 691.0 (M+Na)+.

Sources & evidence

ORD record
ord-f6499520ac154a78b13921f9b32840a6
Source dataset
uspto-grants-2011_02
Patent number
US07893099B2

Reaction notes

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