1-Isopropylpiperazine → HCID 59619366, compound

HRID 1367594Notes

Reaction equation

[CH:1]([N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1)([CH3:3])[CH3:2].[C:10]([C:12]1([NH:15][C:16]([C@H:18]2[CH2:22][C@H:21]([S:23]([C:26]3[CH:31]=[CH:30][C:29](Br)=[CH:28][C:27]=3[C:33]([F:36])([F:35])[F:34])(=[O:25])=[O:24])[CH2:20][C@@H:19]2[O:37][CH:38]2[CH2:42][CH2:41][CH2:40][CH2:39]2)=[O:17])[CH2:14][CH2:13]1)#[N:11].C(C1(NC([C@H]2C[C@H](S(C3C=CC(Br)=CC=3C(F)(F)F)(=O)=O)C[C@@H]2OC)=O)CC1)#N>>[C:10]([C:12]1([NH:15][C:16]([C@H:18]2[CH2:22][C@H:21]([S:23]([C:26]3[CH:31]=[CH:30][C:29]([N:7]4[CH2:8][CH2:9][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6]4)=[CH:28][C:27]=3[C:33]([F:36])([F:35])[F:34])(=[O:25])=[O:24])[CH2:20][C@@H:19]2[O:37][CH:38]2[CH2:42][CH2:41][CH2:40][CH2:39]2)=[O:17])[CH2:14][CH2:13]1)#[N:11]

Participants

Reactant 3

HCID 780131-Isopropylpiperazine

HCID 59619432HCID 59619432, compound

HCID 59619475(1S,2S,4S)-4-(4-Bromo-2-trifluoromethyl-benzenesulfonyl)-2-methoxy-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide

Product 1

HCID 59619366HCID 59619366, compound

Procedure

The title compound was prepared in analogy to example 176 using 1-isopropyl-piperazine instead of morpholine and (1R,2R,4R) and (1S,2S,4S)-4-(4-bromo-2-trifluoromethyl-benzenesulfonyl)-2-cyclopentyloxy-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide (example 195) instead of (1R,2R,4R) and (1S,2S,4S)-4-(4-bromo-2-trifluoromethyl-benzenesulfonyl)-2-methoxy-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide. White solid. MS (EI): 595.4 (M−H)−.

Sources & evidence

ORD record: ord-2f11b46839a24bfca15866afc0cfcd48
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07893099B2

Reaction notes

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