反应详情

To a suspension of sodium hydride (5.63 mg, 0.117 mmol) in ether was added a solution of 2-(4-chloro-phenyl)-propan-2-ol (CAS 1989-25-9) in ether (1.5 ml) at 0° C. The mixture was stirred for 90 minutes, then trichloroacetonitrile (112 μl, 1.11 mmol) was added and stirring was continued for 3 h at 0° C. Then all volatiles were removed and pentane (1 ml) and MeOH (4.74 μl) were added. The suspension was stirred for 1 h. Filtration and concentration of the filtrate yielded the title compound in a mixture with 2-(4-chloro-phenyl)-propan-2-ol which was used in the next reaction step without further purification.

1. stirringstirring
2. waitwas continued for 3 h at 0° C
3. customThen all volatiles were removed
4. additionpentane (1 ml) and MeOH (4.74 μl) were added
5. stirringThe suspension was stirred for 1 h
6. filtrationFiltration and concentration of the filtrate