反应详情

A 200 mL round-bottom flask was charged with 4-morpholin-4-ylmethyl-benzoic acid methyl ester (4.0 g, 0.017 mol, 1.0 eq). A solution of NaOH (2.0 g, 0.051 mol, 3.0 eq) in water was added and the reaction mixture was stirred overnight at room temperature. NaCl (5.0 g) and HCl (6.0 M in water, 17 mL, 6.0 eq) were then added. The reaction mixture was cooled to 0° C. and then stirred for 1 hr. The solid was collected by filtration, washed with pentane and dried at 50° C. under vacuum to yield the title compound as a white solid.

1. temperatureThe reaction mixture was cooled to 0° C.
2. stirringstirred for 1 hr
3. filtrationThe solid was collected by filtration
4. washwashed with pentane
5. customdried at 50° C. under vacuum