Cyclopropylamine → 1-Cyclopropylpiperazine

HRID 1367623Notes

Reaction equation

HRID 1367623 reaction equation
S(O[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]OS(=O)(=O)O)(O)(=O)=O.[CH:16]1([NH2:19])[CH2:18][CH2:17]1>>[CH:16]1([N:19]2[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 407366HCID 407366, compound

Product 1

HCID 47420041-Cyclopropylpiperazine

Conditions

Temperature
50 °C

Procedure

A carousel tube was charged with sulfuric acid mono-[2-(2-sulfooxy-ethylamino)-ethyl]ester (1 g) and D2O (3 mL). To the resulting stirred solution was added then added cyclopropylamin (0.7 mL). The resulting mixture was observed to form a stirrable thick slurry, which was heated at 50° C. overnight. Comparison of the 1H NMR of the title compound with the 1H NMR of the di-hydrochloride salt of the title compound confirmed that the title compound was prepared and present in the resulting solution.

Workup

  1. additionwas added
  2. customto form a stirrable thick slurry, which

Sources & evidence

ORD record
ord-f037756b0a444bdabcd4ebc5d0d19261
Source dataset
uspto-grants-2011_02
Patent number
US07893257B2

Reaction notes

Loading…