HCID 11561933, compound → HCID 11635901, compound

HRID 1367710Notes

Reaction equation

HRID 1367710 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[C@@H:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[N:11]([C:20](Cl)=[O:21])[C:10]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[O:29][CH2:30][CH3:31])=[N:9]2)=[CH:4][CH:3]=1.Cl.Cl.[CH3:34][S:35]([CH2:38][CH2:39][N:40]1[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1)(=[O:37])=[O:36]>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]2[C@@H:12]([C:13]3[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=3)[N:11]([C:20]([N:43]3[CH2:42][CH2:41][N:40]([CH2:39][CH2:38][S:35]([CH3:34])(=[O:36])=[O:37])[CH2:45][CH2:44]3)=[O:21])[C:10]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[O:29][CH2:30][CH3:31])=[N:9]2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 11561933HCID 11561933, compoundHCID 177498851-(2-Methanesulfonylethyl)piperazine dihydrochloride

Product 1

HCID 11635901HCID 11635901, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(4S,5R)-4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 7) was reacted with 1-(2-methanesulfonylethyl)-piperazine bishydrochloride in methylene chloride using the procedure as described in example 8 to give [(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone. HR-MS (ES, m/z) calculated for C31H35N4O4SCl2 [(M+H)+] 629.1751, observed 629.1757.

Sources & evidence

ORD record
ord-2dc030ff75c64ca1b9520ec27b91a1ae
Source dataset
uspto-grants-2011_02
Patent number
US07893278B2

Reaction notes

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