反应详情

30 gms of sertraline base is dissolved in 200 ml of toluene under stirring at room temp. 5 ml acetic acid is added to the clear toluene solution and stirred for 1 hr. at 25° C. to obtain a thick white precipitate. The solids are filtered and re-slurried in 100 ml toluene for 30 minutes and filtered. The product is dried under vacuum at 60° C. for 5-6 hours to give sertraline acetate.

1. stirringstirred for 1 hr
2. customat 25° C. to obtain a thick white precipitate
3. filtrationThe solids are filtered and re-slurried in 100 ml toluene for 30 minutes
4. filtrationfiltered
5. customThe product is dried under vacuum at 60° C. for 5-6 hours