Acetic Acid → HCID 86613018, compound

HRID 1367749Notes

Reaction equation

HRID 1367749 reaction equation
[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1.[C:21]([OH:24])(=[O:23])[CH3:22]>C1(C)C=CC=CC=1>[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1.[C:21]([O-:24])(=[O:23])[CH3:22]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 68617Sertraline

Product 1

HCID 86613018HCID 86613018, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

30 gms of sertraline base is dissolved in 200 ml of toluene under stirring at room temp. 5 ml acetic acid is added to the clear toluene solution and stirred for 1 hr. at 25° C. to obtain a thick white precipitate. The solids are filtered and re-slurried in 100 ml toluene for 30 minutes and filtered. The product is dried under vacuum at 60° C. for 5-6 hours to give sertraline acetate.

Workup

  1. stirringstirred for 1 hr
  2. customat 25° C. to obtain a thick white precipitate
  3. filtrationThe solids are filtered and re-slurried in 100 ml toluene for 30 minutes
  4. filtrationfiltered
  5. customThe product is dried under vacuum at 60° C. for 5-6 hours

Sources & evidence

ORD record
ord-5f67fb7cfc17488699d13e54c42194fa
Source dataset
uspto-grants-2011_02
Patent number
US07893300B2

Reaction notes

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