Hydrochloric Acid → Sertraline Hydrochloride

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Reaction Steps

10 gms of sertraline acetate is dissolved in 100 ml of water at room temperature under stirring. The solution is filtered to obtain a clear solution. To the clear filtrate 5 ml concentrated hydrochloric acid is added drop wise under stirring to adjust pH between 1 to 2. The precipitated solids are stirred for 1 hour at 25° C. and filtered. The solids are dried under vacuum at 60° C. for 8 hours to give sertraline hydrochloride Form V.

Provenance & Evidence