Hydrochloric Acid → Sertraline Hydrochloride

HRID 1367751Notes

Reaction equation

HRID 1367751 reaction equation
[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1.C([O-])(=O)C.[ClH:25]>O>[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1.[ClH:25]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86613018HCID 86613018, compound

Product 1

HCID 63009Sertraline Hydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

10 gms of sertraline acetate is dissolved in 100 ml of water at room temperature under stirring. The solution is filtered to obtain a clear solution. To the clear filtrate 5 ml concentrated hydrochloric acid is added drop wise under stirring to adjust pH between 1 to 2. The precipitated solids are stirred for 1 hour at 25° C. and filtered. The solids are dried under vacuum at 60° C. for 8 hours to give sertraline hydrochloride Form V.

Workup

  1. filtrationThe solution is filtered
  2. customto obtain a clear solution
  3. stirringunder stirring
  4. stirringThe precipitated solids are stirred for 1 hour at 25° C.
  5. filtrationfiltered
  6. customThe solids are dried under vacuum at 60° C. for 8 hours

Sources & evidence

ORD record
ord-b3c87b3c0fa742c08fac21598e4027c0
Source dataset
uspto-grants-2011_02
Patent number
US07893300B2

Reaction notes

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