反应详情

10 gms of sertraline acetate is dissolved in 100 ml of water at room temperature under stirring. The solution is filtered to obtain a clear solution. To the clear filtrate 5 ml concentrated hydrochloric acid is added drop wise under stirring to adjust pH between 1 to 2. The precipitated solids are stirred for 1 hour at 25° C. and filtered. The solids are dried under vacuum at 60° C. for 8 hours to give sertraline hydrochloride Form V.

1. filtrationThe solution is filtered
2. customto obtain a clear solution
3. stirringunder stirring
4. stirringThe precipitated solids are stirred for 1 hour at 25° C.
5. filtrationfiltered
6. customThe solids are dried under vacuum at 60° C. for 8 hours