Hydrochloric Acid → Methyl 4-Iodophenylacetate

HRID 1367783Notes

Reaction equation

HRID 1367783 reaction equation
[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.Cl.[CH3:13]O>O1CCOCC1>[I:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH3:13])=[O:10])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 1372144-Iodophenylacetic acid

Product 1

HCID 10378700Methyl 4-IodophenylacetateYield 98%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a stirred solution of 4-iodophenylacetic acid (5.0 g, 19.1 mmol) in MeOH (200 mL) was added 4N hydrochloric acid in dioxane (10 mL). The reaction mixture was stirred for 24 h at room temperature and then the solvent was removed under reduced pressure to give the title compound (5.17 g, 98% yield), which was used without further purification.

Workup

  1. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-d7f9a2965dab4d11b6398e8bf61d921d
Source dataset
uspto-grants-2011_02
Patent number
US07893256B2

Reaction notes

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