化工社化工社 化学情報印刷レポート · 研究参考用
6-Methoxyisoquinoline-3-carboxylic acid → 3-Isoquinolinecarboxylic acid, 7-methoxy-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Methoxyisoquinoline-3-carboxylic acid | HCID 57306949 | — |
| 反応物 | Boc-7-hydroxy-tetrahydroisoquinoline carboxylic acid | HCID 66940410 | — |
| 生成物 | 3-Isoquinolinecarboxylic acid, 7-methoxy- | HCID 10822014 | 17% |
反応手順
0.25 g (17% in 4 steps) 7-methoxy-isoquinoline-3-carboxylic acid was prepared according to procedure described for the synthesis of 6-methoxy-isoquinoline-3-carboxylic acid (in Example 294) starting from 2.0 g (6.8 mmol) of boc-7-hydroxy-tetrahydroisoquinoline carboxylic acid using 179 mg (0.824 mmol). LCMS: 204 (M+1)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07893267B2 |
| 出典データセット | uspto-grants-2011_02 |
| ORD ID | ord-20822131d2f14539801c82758d84a190 |
| 出典メモ | uspto-grants-2011_02 |