Ammonium Hydroxide → HCID 86608397, compound

HRID 1367982Notes

Reaction equation

[CH3:1][O:2][C:3]1[C:4]([F:17])=[C:5]([C:9]([N+:14]([O-:16])=[O:15])=[C:10](F)[C:11]=1[F:12])[C:6]([OH:8])=[O:7].[OH-].[NH4+:19]>>[NH2:19][C:10]1[C:9]([N+:14]([O-:16])=[O:15])=[C:5]([C:4]([F:17])=[C:3]([O:2][CH3:1])[C:11]=1[F:12])[C:6]([OH:8])=[O:7]

Participants

Reactant 2

HCID 14923Ammonium Hydroxide

HCID 218054742,4,5-Trifluoro-3-methoxy-6-nitrobenzoic acid

Product 1

HCID 86608397HCID 86608397, compoundYield 80%

Procedure

2.0 g (8 mmol) of 3-methoxy-6-nitro-2,4,5-trifluoro-benzoic acid was treated with ammonium hydroxide to produce 1.6 g (6.45 mmol, 80%) of 3-amino-4,6-difluoro-5-methoxy-2-nitro-benzoic acid. LCMS: 249 (M+1)+.

Sources & evidence

ORD record: ord-d1a2409c687641499c5432ee0a58737b
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07893267B2

Reaction notes

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