HCID 12056910, compound → HCID 11816733, compound

HRID 1368018Notes

Reaction equation

HRID 1368018 reaction equation
[Cl:1][C:2]1[C:10]2[O:9][C:8]([CH2:11][CH3:12])=[N:7][C:6]=2[C:5]([N+:13]([O-])=O)=[C:4]([F:16])[CH:3]=1>[Pd].C(OCC)(=O)C.[H][H]>[NH2:13][C:5]1[C:6]2[N:7]=[C:8]([CH2:11][CH3:12])[O:9][C:10]=2[C:2]([Cl:1])=[CH:3][C:4]=1[F:16]

Participants

5

Reactant 1

HCID 12056910HCID 12056910, compound

Product 1

HCID 11816733HCID 11816733, compoundYield 96.7%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolventHCID 178418361HCID 178418361, compoundSolvent

Procedure

Step 5 Palladium on activated carbon (10%, 0.1 g) was added to a solution of 7-chloro-2-ethyl-5-fluoro-4-nitrobenzoxazole (0.86 g) in ethyl acetate (80 ml) and hydrogen was bubbled through the suspension for 5 hours. After filtration and evaporation, 4-amino-7-chloro-2-ethyl-5-fluorobenzoxazole(0.73 g) was obtained as the single product.

Workup

  1. customwas bubbled through the suspension for 5 hours
  2. filtrationAfter filtration and evaporation

Sources & evidence

ORD record
ord-0d8b52d503884327b4e88bd444790a6f
Source dataset
uspto-grants-2003_06
Patent number
US06573218B1

Reaction notes

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