Benzoxazole → 6-[(Oxiran-2-yl)methoxy]quinoline

HRID 1368055Notes

Reaction equation

[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2.[O:12]1[C:16]2[CH:17]=[CH:18]C=CC=2N=C1>>[O:12]1[CH2:16][CH:17]1[CH2:18][O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2

Participants

Reactant 2

HCID 9228Benzoxazole

HCID 113746-Hydroxyquinoline

Product 1

HCID 128209496-[(Oxiran-2-yl)methoxy]quinoline

Procedure

Compound 79 was prepared in the manner of compound 6 substituting 6-hydroxy-quinoline for compound 8 in part C-5 of Example 1.

Sources & evidence

ORD record: ord-c709b3a266564a0ea38d1e93dbf932d3
Source dataset: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06573264B1

Reaction notes

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