Triethylamine → HCID 22591636, compound

HRID 1368057Notes

Reaction equation

HRID 1368057 reaction equation
[NH2:1][CH2:2][CH:3]([OH:23])[CH2:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]([NH:14][C:15]2[C:20]([CH3:21])=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:22])=[O:13])[CH2:7][CH2:6]1.C(N(CC)CC)C.Cl[C:32]1[S:33][C:34]2[CH:40]=[CH:39][CH:38]=[CH:37][C:35]=2[N:36]=1>C(O)C>[S:33]1[C:34]2[CH:40]=[CH:39][CH:38]=[CH:37][C:35]=2[N:36]=[C:32]1[NH:1][CH2:2][CH:3]([OH:23])[CH2:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]([NH:14][C:15]2[C:20]([CH3:21])=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:22])=[O:13])[CH2:7][CH2:6]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 119872-ChlorobenzothiazoleHCID 18519838HCID 18519838, compound

Product 1

HCID 22591636HCID 22591636, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of compound 37 (75 mg) in ethanol (2 mL) was added triethylamine (0.13 mL) and 2-chlorobenzthiazole (87 mg) followed by warming to reflux for 16 h. The reaction mixture was concentrated and purified by preparative TLC (5%MeOH/Dichloromethane) to give Compound 39 as a white solid. Mass Spectrum (MH+)=454.4.

Workup

  1. temperatureby warming
  2. temperatureto reflux for 16 h
  3. concentrationThe reaction mixture was concentrated
  4. custompurified by preparative TLC (5%MeOH/Dichloromethane)

Sources & evidence

ORD record
ord-6dcdb480d3ee487da3066d3944cec5fb
Source dataset
uspto-grants-2003_06
Patent number
US06573264B1

Reaction notes

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