反应详情

10% Palladium on carbon catalyst (water content 53.8%, 500 mg) was added to ethanol (30 ml) solution of 3-(R)-[1-(tert-butoxycarbonyl)amino-1-cyclobutyl]methyl-1-[1-(R)-phenylethyl]pyrrolidine (isomer B1) (516 mg, 1.44 mmol), and the mixture was subjected to 5 hours of catalytic hydrogenation at an external temperature of 50C in an atmosphere of hydrogen under atmospheric pressure. The reaction solution was filtered and the solvent was evaporated under a reduced pressure, thereby obtaining 366 mg (quantitative) of the title compound as colorless crystals. This product was used in the subsequent reaction without purification.

1. filtrationThe reaction solution was filtered
2. customthe solvent was evaporated under a reduced pressure