HCID 21087446, compound → HCID 21087444, compound

Participants

Reaction Steps

10% Palladium on carbon catalyst (water content 53.8%, 500 mg) was added to ethanol (30 ml) solution of 3-(R)-[1-(tert-butoxycarbonyl)amino-1-cyclobutyl]methyl-1-[1-(R)-phenylethyl]pyrrolidine (isomer B1) (516 mg, 1.44 mmol), and the mixture was subjected to 5 hours of catalytic hydrogenation at an external temperature of 50C in an atmosphere of hydrogen under atmospheric pressure. The reaction solution was filtered and the solvent was evaporated under a reduced pressure, thereby obtaining 366 mg (quantitative) of the title compound as colorless crystals. This product was used in the subsequent reaction without purification.

Provenance & Evidence