Fumaric Acid → HCID 69831977, compound

HRID 1368195Notes

Reaction equation

HRID 1368195 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH2:9][N:8]([C:15]([C@H:17]1[CH2:22][CH2:21][CH2:20][N:19]([CH2:23][CH2:24][C:25]([NH:27][C:28]3[CH:33]=[CH:32][C:31]4[O:34][CH2:35][O:36][C:30]=4[CH:29]=3)=[O:26])[CH2:18]1)=[O:16])[CH2:7][CH2:6]2.[C:37]([OH:44])(=[O:43])/[CH:38]=[CH:39]/[C:40]([OH:42])=[O:41]>C(O)C>[C:37]([OH:44])(=[O:43])/[CH:38]=[CH:39]/[C:40]([OH:42])=[O:41].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH2:9][N:8]([C:15]([C@H:17]1[CH2:22][CH2:21][CH2:20][N:19]([CH2:23][CH2:24][C:25]([NH:27][C:28]3[CH:33]=[CH:32][C:31]4[O:34][CH2:35][O:36][C:30]=4[CH:29]=3)=[O:26])[CH2:18]1)=[O:16])[CH2:7][CH2:6]2

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 12071996HCID 12071996, compound

Product 1

HCID 69831977HCID 69831977, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a ethanol solution of 9.32 g of (±)-3-[(S)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]-N-(3,4-methylenedioxyphenyl)propanamide was added 2.07 g of fumaric acid, and the mixture was evaporated in vacuo. Thus, 9.38 g of (±)-3-[(S)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]-N-(3,4-methylenedioxyphenyl)propanamide fumarate was obtained as colorless crystals from ethanol/2-butanone.

Workup

  1. customthe mixture was evaporated in vacuo

Sources & evidence

ORD record
ord-02bd1b6e0ce44f0597e392876023d011
Source dataset
uspto-grants-2003_06
Patent number
US06573279B1

Reaction notes

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