Hydrazine hydrate (1:1) → HCID 135824734, compound

HRID 1368286Notes

Reaction equation

HRID 1368286 reaction equation
Cl.[C:2]1([CH2:12][C:13]([NH2:15])=[NH:14])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.O.[NH2:17]N.[C:19]([NH:22][CH:23]([CH3:31])[C:24](=O)[C:25](OCC)=[O:26])(=[O:21])[CH3:20]>>[C:2]1([CH2:12][C:13]2[NH:15][C:25](=[O:26])[C:24]([CH:23]([NH:22][C:19](=[O:21])[CH3:20])[CH3:31])=[N:17][N:14]=2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 13980433HCID 13980433, compoundHCID 22245807Ethyl 3-acetamido-2-oxobutanoate

Product 1

HCID 135824734HCID 135824734, compound

Procedure

Analogously to Example 10A, 1.67 g (8.00 mmol) of 2-(1-naphthyl)ethanamidine hydrochloride are reacted with 401 mg (8.00 mmol) of hydrazine hydrate and 2.70 g (14.4 mmol) of ethyl 3-(acetylamino)-2-oxobutanoate to give N-{1-[3-(1-naphthylmethyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}acetamide.

Sources & evidence

ORD record
ord-3fe51a35c4cd48e1b4c736059a98a397
Source dataset
uspto-grants-2003_06
Patent number
US06573263B2

Reaction notes

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