HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]propyl}acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Ethyl 3-acetamido-2-oxopentanoate | HCID 21935058 | — |
| Reactant | 2-(3,4-Dimethoxyphenyl)ethanimidamide hydrochloride | HCID 22245813 | — |
| Product | N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]propyl}acetamide | HCID 135824713 | — |
Reaction Steps
Analogously to Example 10A, 9.75 g (42.3 mmol) of 2-(3,4-dimethoxyphenyl)ethanamidine hydrochloride are reacted with 2.54 g (50.7 mmol) of hydrazine hydrate and 12.8 g (63.4 mmol) of ethyl 3-(acetylamino)-2-oxopentanoate to give N-{1-[3-(3,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]propyl}acetamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06573263B2 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-7c97430ff9ee413381de076c9de2805b |
| Source note | uspto-grants-2003_06 |