Phosphorus oxychloride → 7-(1-acetyl-4-phenylbutyl)-2-(3-ethoxy-4-methoxybenzyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one
Reaction equation
[C:1]([CH:4]([CH2:30][CH2:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:5]([NH:7][CH:8]([C:11]1[C:12](=[O:29])[NH:13][C:14]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH2:27][CH3:28])[CH:19]=2)=[N:15][N:16]=1)[CH2:9]C)=O)(=[O:3])[CH3:2].P(Cl)(Cl)(Cl)=O>>[C:1]([CH:4]([C:5]1[N:16]2[C:11]([C:12](=[O:29])[NH:13][C:14]([CH2:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH2:27][CH3:28])[CH:19]=3)=[N:15]2)=[C:8]([CH3:9])[N:7]=1)[CH2:30][CH2:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)(=[O:3])[CH3:2]Participants
3
Procedure
Analogously to Example 1, 123 mg (0.24 mmol) of 2-acetyl-N-{1-[3-(3-ethoxy-4-methoxybenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]propyl}-5-phenylpentanamide and 41.0 mg (0.27 mmol) of phosphorus oxychloride are reacted to give 7-(1-acetyl-4-phenylbutyl)-2-(3-ethoxy-4-methoxybenzyl)-5-methylimidazo[5,1-f][1 ,2,4]triazin-4(3H)-one.
Sources & evidence
- ORD record
- ord-d72145f21e6340c6829e5ab6acb241d9
- Source dataset
- uspto-grants-2003_06
- Patent number
- US06573263B2
Reaction notes
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