Phosphorus oxychloride → 7-(1-acetyl-4-phenylbutyl)-5-methyl-2-(1-naphthylmethyl)imidazo[5,1-f][1,2,4]triazin-4(3H)-one
Reaction equation
[C:1]([CH:4]([CH2:28][CH2:29][CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:5]([NH:7][CH:8]([C:10]1[C:11](=[O:27])[NH:12][C:13]([CH2:16][C:17]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH:20]=[CH:19][CH:18]=2)=[N:14][N:15]=1)[CH3:9])=O)(=[O:3])[CH3:2].P(Cl)(Cl)(Cl)=O>>[C:1]([CH:4]([C:5]1[N:15]2[C:10]([C:11](=[O:27])[NH:12][C:13]([CH2:16][C:17]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[CH:20]=[CH:19][CH:18]=3)=[N:14]2)=[C:8]([CH3:9])[N:7]=1)[CH2:28][CH2:29][CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)(=[O:3])[CH3:2]Participants
3
Procedure
Analogously to Example 1, 80 mg (0.17 mmol) of 2-acetyl-N-{1-[3-(1-naphthylmethyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]ethyl}-5-phenylpentanamide and 28.0 mg (0.18 mmol) of phosphorus oxychloride are reacted to give 7-(1-acetyl-4-phenylbutyl)-5-methyl-2-(1-naphthylmethyl)imidazo[5,1-f][1,2,4]triazin-4(3H)-one.
Sources & evidence
- ORD record
- ord-c6380532bc91496c926e6c5e748b3486
- Source dataset
- uspto-grants-2003_06
- Patent number
- US06573263B2
Reaction notes
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