反应详情

To 2,4-dihydroxybenzamide (16.5 g, 108.3 mmol) in DMF (100 mL) was added Cs2CO3 (39.0 g, 119.1 mmol) followed by ethyl 4-bromobutyrate (17.0 mL, 119.1 mmol). The mixture was heated to 70 OC for 2 h, cooled, diluted with water and extracted with EtOAc. The combined extracts were washed with water, dried over magnesium sulfate, concentrated, and chomatographed over silica gel (60% EtOAc/hexane) to a white solid (4.2 g, 15%). MS [M+H]+ 267.

1. temperatureThe mixture was heated to 70 OC for 2 h
2. temperaturecooled
3. extractionextracted with EtOAc
4. washThe combined extracts were washed with water
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated