反应详情

温度

60 °C

Potassium carbonate (0.55 g) and 1-bromooctadecane (0.67 g) were added to a solution containing N-[3-(dimethylamino)propyl]-3-(2-hydroxyphenyl)propanamide (0.50 g) obtained in Example 1(1) in acetone (5 ml). After being stirred for 24 hours at 60° C., the reaction mixture was concentrated. The residue, with ethyl acetate added thereto, was washed with water and brine successively, dried over sodium sulfate anhydride, and concentrated. The residue was purified by silica gel column chromatography (silica gel 40 g, chloroform: methanol=10:1), thereby yielding the entitled compound (0.42 g) as white solid.

1. concentrationthe reaction mixture was concentrated
2. additionThe residue, with ethyl acetate added
3. washwas washed with water and brine successively
4. dry with materialdried over sodium sulfate anhydride
5. concentrationconcentrated
6. customThe residue was purified by silica gel column chromatography (silica gel 40 g, chloroform: methanol=10:1)