1-(4-Methylpiperazino)-3-[2-(octadecyloxy)phenyl]-1-propanone → HCID 18520285, compound

HRID 1368378Notes

Reaction equation

HRID 1368378 reaction equation
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]1[CH2:14][CH2:13][N:12]([C:15](=[O:43])[CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])[CH2:11][CH2:10]1>C(OCC)(=O)C>[ClH:1].[CH3:8][N:9]1[CH2:10][CH2:11][N:12]([C:15](=[O:43])[CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])[CH2:13][CH2:14]1

Participants

4

Reactant 2

HCID 98071961-(4-Methylpiperazino)-3-[2-(octadecyloxy)phenyl]-1-propanoneHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 18520285HCID 18520285, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (0.24 ml) was added to a solution containing 1-(4-methylpiperazino)-3-[2-(octadecyloxy)phenyl]-1-propanone (0.38 g) in ethyl acetate (4 ml) at room temperature. After being stirred for 15 minutes, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethyl acetate-ethanol, thereby yielding the entitled compound (0.38 g) as white solid.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized with the mixed solution of ethyl acetate-ethanol

Sources & evidence

ORD record
ord-5f6090bb28c64224a2a141e942da5a52
Source dataset
uspto-grants-2003_06
Patent number
US06573297B2

Reaction notes

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