2-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-tetradecylcarbamate → 2-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-tetradecylcarbamate Hydrochloride

HRID 1368380Notes

Reaction equation

HRID 1368380 reaction equation
[ClH:1].C(OCC)(=O)C.[CH2:8]([NH:22][C:23](=[O:42])[O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[CH2:31][CH2:32][C:33]([N:35]1[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]1)=[O:34])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]>C(OCC)(=O)C>[ClH:1].[CH2:8]([NH:22][C:23](=[O:42])[O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[CH2:31][CH2:32][C:33]([N:35]1[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]1)=[O:34])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]

Participants

4

Reactant 2

HCID 99571202-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-tetradecylcarbamateHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 185202772-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-tetradecylcarbamate Hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (1.48 ml) was added to a solution containing 2-[3-(4-methylpiperazino)-3-oxopropyl]phenyl N-tetradecylcarbamate (2.40 g) in ethyl acetate (24 ml) while being cooled with ice. After being stirred for 45 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethyl acetate-ethanol, thereby yielding the entitled compound (2.22 g) as white solid.

Workup

  1. temperaturewhile being cooled with ice
  2. concentrationthe reaction mixture was concentrated
  3. customThe residue was recrystallized with the mixed solution of ethyl acetate-ethanol

Sources & evidence

ORD record
ord-70a614a6a8664574adea184f0bfb60b1
Source dataset
uspto-grants-2003_06
Patent number
US06573297B2

Reaction notes

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