反应详情

Triethylamine (1.06 ml) and octadecyl isocyanate (2.35 ml) were added to a solution containing 2-(2-hydroxyphenyl)-1-(4-methylpiperazino)-1-ethanone (1.60 g) in methylene chloride (16 ml) and stirred for 15.5 hours at room temperature. The insoluble matters were filtrated out and washed with chloroform. The filtrate and washings were combined and the mixture was washed with saturated sodium hydrogencarbonate aqueous solution and brine successively, dried over sodium sulfate anhydride, and concentrated. The residue was purified by silica gel column chromatography (silica gel 100 g, chloroform:methanol=50:1 to 30:1), thereby yielding the entitled compound (3.23 g) as white solid.

1. filtrationThe insoluble matters were filtrated out
2. washwashed with chloroform
3. washthe mixture was washed with saturated sodium hydrogencarbonate aqueous solution and brine successively
4. dry with materialdried over sodium sulfate anhydride
5. concentrationconcentrated
6. customThe residue was purified by silica gel column chromatography (silica gel 100 g, chloroform:methanol=50:1 to 30:1)