HCID 178418816, compound → HCID 178487501, compound

HRID 1368519Notes

Reaction equation

HRID 1368519 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]([C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([O:18][CH3:19])[CH:14]=3)[CH:9]=2)=[O:7])[N:3]=[CH:2]1.[CH2:20]([Mg]Br)[CH:21]([CH3:23])[CH3:22]>C1COCC1>[NH:1]1[CH:5]=[C:4]([C:6]([C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([O:18][CH3:19])[CH:14]=3)[CH:9]=2)([OH:7])[CH2:20][CH:21]([CH3:23])[CH3:22])[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 178418816HCID 178418816, compoundHCID 178487490HCID 178487490, compound

Product 1

HCID 178487501HCID 178487501, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a similar manner to that described in Example 1-(iv), the reaction of (1H-imidazol-4-yl)-(6-methoxynaphthalen-2-yl)ketone (0.60 g) with absolution of isobutylmagnesium bromide in THF (1.0 M, 2.4 ml) was carried out to give the titled compound (0.14 g) as a colorless solid.

Sources & evidence

ORD record
ord-dc1d339bc98e42a4b37c0346034510b4
Source dataset
uspto-grants-2003_06
Patent number
US06573289B1

Reaction notes

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