反应详情

温度

60 °C

4-[1-Methoxy-1-(6-methoxynaphthalen-2-yl)ethyl]-1-trityl-1H-imidazole (1.5 g) and pyridine hydrochloride (500 mg) were dissolved in methanol (8 ml). The solution was stirred at 60° C. for 2 h. After cooling, 1 N-hydrochloric acid was added to the solution, and precipitate was filtered off. The filtrate was washed with ether and neutralized with potassium carbonate. The filtrate was extracted with ethyl acetate, washed with saturated aqueous solution of sodium chloride, dried and concentrated. The residue was purified by silica gel column chromatography (eluent, ethyl acetate:methanol=30:1) to give the titled compound (0.33 g) as a colorless powder.

1. temperatureAfter cooling
2. filtrationwas filtered off
3. washThe filtrate was washed with ether and neutralized with potassium carbonate
4. extractionThe filtrate was extracted with ethyl acetate
5. washwashed with saturated aqueous solution of sodium chloride
6. customdried
7. concentrationconcentrated
8. customThe residue was purified by silica gel column chromatography (eluent, ethyl acetate:methanol=30:1)