反应详情

1-(6-Bromo-2-methoxynaphthalen-1-yl)ethanol (18.57 g) and tert-butyldimethylchlorosilane (11.40 g) were dissolved in DMF (300 ml). To the solution was added imidazole (13.20 g), and the mixture was stirred at room temperature for 14 h. The reaction mixture was concentrated, and to the residue were added water and ethyl acetate. The organic layer was washed with water and saturated solution of sodium chloride, dried and concentrated to give the titled compound (25.58 g) as a colorless liquid.

1. concentrationThe reaction mixture was concentrated
2. additionto the residue were added water and ethyl acetate
3. washThe organic layer was washed with water and saturated solution of sodium chloride
4. customdried
5. concentrationconcentrated