HCID 22018460, compound → HCID 22018435, compound

HRID 1368562Notes

Reaction equation

HRID 1368562 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]([C:15]1[S:19][CH:18]=[N:17][CH:16]=1)[OH:14])[CH:7]=[CH:6]2>ClCCl.[O-2].[O-2].[Mn+4]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C:13]([C:15]1[S:19][CH:18]=[N:17][CH:16]=1)=[O:14])[CH:7]=[CH:6]2

Participants

4

Reactant 1

HCID 22018460HCID 22018460, compound

Product 1

HCID 22018435HCID 22018435, compoundYield 86.1%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

(6-methoxynaphthalen-2-yl)(thiazol-5-yl)methanol (2.0 g) was dissolved in dichloromethane (30 ml). To the solution was added manganese dioxide (6.0 g), and the mixture was stirred at room temperature for 3 h. The mixture was filtered with celite and the cake was rinsed with dichloromethane. The filtrate was concentrated and the obtained residue was recrystallized from ethyl acetate to give the titled compound (1.71 g) as a pale yellow powder.

Workup

  1. filtrationThe mixture was filtered with celite
  2. washthe cake was rinsed with dichloromethane
  3. concentrationThe filtrate was concentrated
  4. customthe obtained residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-862ad7b7582c4f55b47c009936194fb9
Source dataset
uspto-grants-2003_06
Patent number
US06573289B1

Reaction notes

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