Ammonium Chloride → HCID 22281969, compound

HRID 1368660Notes

Reaction equation

HRID 1368660 reaction equation
C([O:4][CH2:5][CH2:6][O:7][C:8]1[C:12]([C:13]2[CH:21]=[CH:20][C:16]3[O:17][CH2:18][O:19][C:15]=3[CH:14]=2)=[C:11]([NH2:22])[N:10]([CH3:23])[N:9]=1)(=O)C.[Na].[Cl-].[NH4+]>C(O)C.O>[NH2:22][C:11]1[N:10]([CH3:23])[N:9]=[C:8]([O:7][CH2:6][CH2:5][OH:4])[C:12]=1[C:13]1[CH:21]=[CH:20][C:16]2[O:17][CH2:18][O:19][C:15]=2[CH:14]=1

Participants

6

Reactant 3

HCID 25517Ammonium ChlorideHCID 5360545SodiumHCID 23400310HCID 23400310, compound

Product 1

HCID 22281969HCID 22281969, compoundYield 97.9%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 2-{[5-amino-4-(1,3-benzodioxol-5-yl)-1-methyl-1H-pyrazol-3-yl]oxy}ethyl acetate (100 mg) (Preparation 33) in ethanol (6 ml) at room temperature, was added sodium hydroxyde (10 mg). After one hour, the reaction was diluted with water (5 ml ) and an aqueous saturated solution of ammonium chloride (10 ml ). The mixture was extracted with ethyl acetate (3×6 ml). The organic fraction was dried over sodium sulfate and concentrated under reduced pressure to yield the title compound as a white solid (85 mg).

Workup

  1. extractionThe mixture was extracted with ethyl acetate (3×6 ml)
  2. dry with materialThe organic fraction was dried over sodium sulfate
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-69de71fae24144ba8b22328d74832713
Source dataset
uspto-grants-2003_06
Patent number
US06573270B1

Reaction notes

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