Guanidine → Eniporide

HRID 1368750Notes

Reaction equation

HRID 1368750 reaction equation
[CH3:1][C:2]1[CH:11]=[C:10]([N:12]2[CH:16]=[CH:15][CH:14]=[CH:13]2)[C:9]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:8][C:3]=1[C:4](OC)=[O:5].[NH2:21][C:22]([NH2:24])=[NH:23]>>[NH2:23][C:22]([NH2:24])=[N:21][C:4](=[O:5])[C:3]1[CH:8]=[C:9]([S:17]([CH3:20])(=[O:19])=[O:18])[C:10]([N:12]2[CH:16]=[CH:15][CH:14]=[CH:13]2)=[CH:11][C:2]=1[CH3:1]

Participants

3

Reactant 2

HCID 3520GuanidineHCID 10780055HCID 10780055, compound

Product 1

HCID 6433092Eniporide

Procedure

in stage g) by reaction of methyl 2-methyl-4-(1-pyrrolyl)-5-methylsulfonylbenzoate with guanidine to give the end-product N-diaminomethylene-2-methyl-4-(1-pyrrolyl)-5-methylsulfonylbenzamide, the guanidino group is introduced.

Sources & evidence

ORD record
ord-5123b3b45ae24f9692a489df5f32958d
Source dataset
uspto-grants-2003_06
Patent number
US06573404B2

Reaction notes

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