Carbon Dioxide → 4-Chloro-2-methylbenzoic acid

HRID 1368756Notes

Reaction equation

HRID 1368756 reaction equation
NC(N)=NC(=O)C1C=C(S(C)(=O)=O)C(S(C)(=O)=O)=CC=1C.Br[C:23]1[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][C:24]=1[CH3:30].[C:31](=[O:33])=[O:32]>>[Cl:29][C:26]1[CH:27]=[CH:28][C:23]([C:31]([OH:33])=[O:32])=[C:24]([CH3:30])[CH:25]=1

Participants

4

Reactant 3

HCID 280Carbon DioxideHCID 844762-Bromo-5-chlorotolueneHCID 9799487N-(2-Methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine

Product 1

HCID 3482694-Chloro-2-methylbenzoic acid

Procedure

In a process for preparing N-diaminomethylene-2-methyl-4,5-di(methylsulfonyl)benzamide, the step comprising reacting 2-bromo-5-chlorotoluene with a secondary or tertiary organolithium compound and CO2 to produce 4-chloro-2-methylbenzoic acid.

Sources & evidence

ORD record
ord-8be301c50dbe41088f92d51e48345868
Source dataset
uspto-grants-2003_06
Patent number
US06573404B2

Reaction notes

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