Dipotassium 2,3-dihydroxybutanedioate → HCID 18520529, compound

HRID 1368772Notes

Reaction equation

HRID 1368772 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:6]=[C:7]3[C:14](=O)[NH:13][CH2:12][CH2:11][N:8]3[C:9]=2[CH:10]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].C([O-])(=O)C(C(C([O-])=O)O)O.[K+].[K+]>O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:6]=[C:7]3[CH2:14][NH:13][CH2:12][CH2:11][N:8]3[C:9]=2[CH:10]=1

Participants

5

Reactant 3

HCID 6100505Dipotassium 2,3-dihydroxybutanedioateHCID 18520536HCID 18520536, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 18520529HCID 18520529, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

A 0.47 g portion of the compound obtained in Example 8- (5) was suspended in 50 ml of tetrahydrofuran, mixed with 0.2 g of lithium aluminum hydride and then stirred at 60° C. for 8 hours. The reaction solution was cooled to 0° C., mixed carefully with saturated potassium tartarate aqueous solution to terminate the reaction and then extracted with chloroform. The organic layer was washed with saturated brine and dried with anhydrous sodium sulfate, and then the solvent was evaporated to obtain 0.46 g of the title compound.

Workup

  1. temperatureThe reaction solution was cooled to 0° C.
  2. customto terminate
  3. customthe reaction
  4. extractionextracted with chloroform
  5. washThe organic layer was washed with saturated brine
  6. dry with materialdried with anhydrous sodium sulfate
  7. customthe solvent was evaporated

Sources & evidence

ORD record
ord-1194f3516dee4a089eeaabcd1f69b2e5
Source dataset
uspto-grants-2003_06
Patent number
US06573377B1

Reaction notes

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