Potassium Carbonate → HCID 18520531, compound

HRID 1368777Notes

Reaction equation

HRID 1368777 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)[N:3]=1.Cl.[OH:20][CH:21]1[CH2:24][NH:23][CH2:22]1.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[Cl:8][C:6]1[N:7]=[C:2]([N:23]2[CH2:24][CH:21]([OH:20])[CH2:22]2)[N:3]=[C:4]([NH:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)[N:5]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27592903-Hydroxyazetidine hydrochlorideHCID 11300612HCID 11300612, compound

Product 1

HCID 18520531HCID 18520531, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 1.47 g (5.16 mmol) portion of 2,4-dichloro-6-(4-methoxybenzylamino)-1,3,5-triazine was suspended in 100 ml of ethanol, mixed with 568 mg (5.18 mmol) of 3-hydroxyazetidine hydrochloride and 1.43 g of potassium carbonate and stirred at room temperature for 7 hours. After evaporation of the solvent under a reduced pressure, water was added to the residue and the resulting precipitate was collected by filtration to obtain 1.54 g (93%) of the title compound as a white powder.

Workup

  1. customAfter evaporation of the solvent under a reduced pressure, water
  2. additionwas added to the residue
  3. filtrationthe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-1a18393df123445a85378ff27a1bd1e3
Source dataset
uspto-grants-2003_06
Patent number
US06573377B1

Reaction notes

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